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外阴表皮内Paget氏病可伴发腺癌,因此,外阴切除为其首选疗法。然而在切除之边缘常复发,如再行切除往往又失败,且可发生类似于原发病的瘙痒及灼热症状。争光霉素在鳞状细胞组织中浓度高,已证明对起源于鳞状细胞的肿瘤有效,因此作者选择它作局部化疗。药物制备:105毫克硫酸争光霉素溶于1毫升蒸馏水,再与2克Aquaphor基质混匀制成3.5%的疏水性软膏3克,置冰箱保存,有效期30天。 7例复发性外阴Paget氏病患者,洗清患部,保护周围正常皮肤,外用3.5%的争光霉素软膏,每日2次。每2周为一疗程,两疗程间休息4～6周,无1例超过4个疗程。遇下列情况即中止治疗:(1)主
Paget’s disease in the vulvar epidermis can be associated with adenocarcinoma, therefore, vulvar resection is the preferred therapy. However, the recurrence of the edge of the recurrence, such as resection often fail, and may occur similar to the primary disease of itching and burning symptoms. Bleomycin is highly concentrated in squamous tissue and has been shown to be effective in tumors of squamous cell origin, so the authors chose it for topical chemotherapy. Drug Preparation: 105 mg of bleomycin sulphate dissolved in 1 ml of distilled water, and then mix with 2 grams of Aquaphor matrix made of 3.5% hydrophobic ointment 3 grams, set the refrigerator to save, valid for 30 days. 7 cases of recurrent genital Paget’s disease patients, wash the affected area to protect the surrounding normal skin, topical 3.5% of glibamycin ointment, 2 times a day. Every 2 weeks for a course of treatment, two courses of rest 4 to 6 weeks, no more than 4 cases of treatment. Case of the following cases that stop treatment: (1) Lord