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目的:分析输尿管软镜碎石术联合体外超声波碎石与经皮肾镜碎石取石术治疗2～4 cm肾结石的临床疗效及患者满意度。方法:回顾性分析2017年7月—2019年10月徐州医科大学附属医院收治的136例结石最大直径为2～4 cm的肾结石患者的病例资料，根据治疗方法不同将其分为两组：观察组(n n＝66)和对照组(n n＝70)。观察组患者采用输尿管软镜碎石术联合术后体外超声波碎石治疗，对照组患者采用经皮肾镜碎石取石术治疗。分析比较两组患者的血红蛋白值、白细胞计数、术后并发症、结石清除率、住院费用、术后住院时间、手术时间、术后满意度及再次手术选择率。计量资料以均数±标准差(n Mean±n SD)表示，组间比较采用n t检验；计数资料组间比较采用n χ2检验。n 结果:两组患者的结石清除率(81.82%比85.71%)、术后白细胞计数[(7.91±2.33)×10n 9/L比(8.69±2.76)×10n 9/L]、住院费用[(2.86±0.57)万元比(3.01±1.16)万元]、术后满意度(81.82%比74.29%)比较，差异均无统计学意义(n P>0.05)。在术后住院时间[(1.99±1.27) d比(5.25±3.18) d]、术后血红蛋白下降值[(7.16±6.11) g/L比(15.14±8.69) g/L]、术后并发症发生率(12.1%比45.7%)方面，观察组均低于对照组，差异具有统计学意义(n P<0.05)。在手术时间[(100.13±47.65)min比(75.66±30.17) min]、再次手术选择率(96.97%比65.71%)方面，观察组均高于对照组，差异具有统计学意义(n P0.05). Postoperative hospital stay [(1.99±1.27) dn vs (5.25±3.18) d], postoperative hemoglobin drop [(7.16±6.11) g/L n vs (15.14±8.69) g/L], incidence of postoperative complications (12.1% n vs 45.7%), the observation group was lower than the control group, and the difference were statistically significant (n P<0.05). In terms of operation time [(100.13±47.65) minn vs (75.66±30.17) min] and the repeated selection rate of operation methods (96.97% n vs 65.71%), the observation group was higher than the control group, and the difference was statistically significant (n P<0.05) .n Conclusion:The clinical efficacy of FURL combined with ESWL in the treatment of 2- 4 cm renal calculus is better, which is beneficial to lower rate of postoperative complications, higher degree of patients’ satisfaction, and it is worthy of popularization and application.