世界上每年约有150,000名儿童出生时有先天性畸形;自然流产的胚胎中有50～60%有染色体畸变;死胎中有5%为染色体畸变,对于家庭在无论精神上还是经济上都是一个巨大的负担。近十年来由于开展了羊水内胎儿脱落细胞的培养,进行产前诊断,以了解胎儿染色体核型分析和生化测定后,面减少了先天畸形儿的出生。现将羊水培养方面近年来的进展简述如下。 Approximately 150,000 children are born with congenital malformations every year in the world; 50-60% of spontaneous abortions have chromosomal aberrations; and 5% of stillbirths have chromosomal aberrations that are neither financial nor psychologically Huge burden. In the past decade as a result of amniotic fluid fetus in vitro cell culture, prenatal diagnosis to understand fetal karyotype analysis and biochemical determination, the surface reduces birth congenital malformation children. Now the progress of amniotic fluid culture in recent years are summarized as follows.