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目的:观察糖皮质激素联合特布他林治疗慢阻肺急性加重期患者的疗效。方法:68例纳入观察的患者随机分为两组各34例,均接受吸氧、抗生素、排痰等对症处理,对照组雾化吸入特布他林,观察组在对照组基础上雾化吸入布地奈德,2周后对比疗效。结果:治疗后两组患者的FEV1和FEV1/FVC均有不同程度上升,而N%和hs-CRP则有不同程度下降,差异均有统计学意义(aP<0.05);治疗后两组组间对比,观察组患者的FEV1和FEV1/FVC均高于对照组,而N%和hs-CRP则低于对照组,差异均有统计学意义(bP<0.05)。结论:糖皮质激素联合特布他林治疗慢阻肺急性加重期疗效确切,能进一步改善患者的肺功能,值得临床应用。
Objective: To observe the effect of glucocorticoid combined with terbutaline on patients with acute exacerbation of chronic obstructive pulmonary disease. Methods: Sixty-eight patients enrolled in the study were randomly divided into two groups of 34 patients. All patients received symptomatic treatment with oxygen inhalation, antibiotics and expectoration. In the control group, terbutaline was inhaled by nebulization. In the observation group, nebulized inhalation Budesonide, 2 weeks after the comparison of efficacy. Results: After treatment, FEV1 and FEV1 / FVC of both groups increased to some extent, while N% and hs-CRP decreased to some extent, the differences were statistically significant (aP <0.05); after treatment, In contrast, FEV1 and FEV1 / FVC in the observation group were significantly higher than those in the control group, while those in the control group were significantly lower (p <0.05). Conclusion: Glucocorticoids combined with Terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease has definite curative effect, which can further improve the lung function of patients and is worthy of clinical application.