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顺铂是目前常用的有效抗癌药物之一,但也最易引起呕吐.既往在肺癌用含顺铂的方案进行化疗时,多用大剂量胃复安进行止呕,但有近40%仍不能完全免除恶心与呕吐.昂丹司琼(枢丹)是一种国产的5—HT_3受体的拮抗剂,它的止呕功效优于大剂量的胃复安,且有学者报告皮质类固醇与其联用能增强它的疗效.我们自1998年2月～1998年7月对52例肺癌患者行含顺铂方案化疗同时,用枢丹进行业呕,观察其加或不加甲强龙对急性和迟发性呕吐反应的影响.现报告如下:
Cisplatin is one of the commonly used effective anti-cancer drugs, but it is also the most likely cause of vomiting. In the past when lung cancer was treated with chemotherapy containing cisplatin, high-dose metoclopramide was used for vomiting, but nearly 40% of them could not Complete elimination of nausea and vomiting. Ondansetron (Zhudan) is a domestic 5-HT3 receptor antagonist. Its antiemetic effect is superior to large doses of metoclopramide, and some scholars have reported that corticosteroids are associated with it. The efficacy can be enhanced by its use. From February 1998 to July 1998, 52 patients with lung cancer were treated with chemotherapy containing cisplatin. At the same time, they were treated with Gandan for vomiting, and they were observed with or without methylprednisolone. The effects of delayed vomiting reactions are as follows: