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目的：分析超抗原活化的外周血ＣＤ＋４Ｔ细胞Ｔｈ１／Ｔｈ２的平衡状况。方法：在体外检测了细胞因子及细胞因子受体水平。结果：ＳＥＢ能诱导外周血淋巴细胞增殖；增殖反应发生在ＳＥＢ刺激后的ｄ３；６细胞增殖达到高峰，随后下降。而ｍＩＬ－２Ｒ的表达在刺激后的ｄ３表现出明显升高（Ｐ＜０．０１），比ｓＩＬ－２Ｒ的释放提前了３ｄ。ＩＬ－２的释放在刺激后的ｄ３到ｄ４达到高峰；ＩＬ－４的水平为０。结论：早期ｍＩＬ－２Ｒ的表达与后期细胞增殖有关。增殖的细胞是Ｔｈ１而不是Ｔｈ２。
Objective: To analyze the balance of Th1 / Th2 in superantigen activated peripheral blood CD + 4T cells. Methods: Cytokines and cytokine receptor levels were examined in vitro. Results: SEB could induce the proliferation of peripheral blood lymphocytes; the proliferative response occurred at d3 after SEB stimulation; the proliferation of 6 cells peaked and then decreased. However, the expression of mIL-2R was significantly increased after stimulation (P <0.01), which was 3 days earlier than that of sIL-2R. The release of IL-2 peaked from d3 to d4 after stimulation; the level of IL-4 was zero. Conclusion: The expression of early mIL-2R is related to cell proliferation in later stage. Proliferating cells are Th1 but not Th2.