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目的:评价中西药结合治疗对母儿ABO血型不合的疗效以及新生儿溶血发生与孕次关系的探讨。方法:对314例抗体滴度≥l:64的ABO母儿血型不合孕妇(20-45岁)进行研究,其中246例孕期给予以中西药结合治疗(茵陈蒿汤联合25%葡萄糖液、维生素C、维生素E、苯巴比妥),68例作为对照,观察孕妇IgG抗A/B抗体效价变化及新生儿溶血发生情况。结果:治疗组抗体效价降低与对照组相比,差异有统计学意义(P<0.05),治疗组新生儿溶血发生率与对照组相比,差异有统计学意义(P<0.05)。孕次越大,新生儿溶血的发生率越高。结论:中西药结合治疗对降低孕妇IgG抗A/B效价及防治新生儿溶血疗效满意,新生儿溶血发生可能与孕次呈正相关。
Objective: To evaluate the curative effect of combination therapy of Chinese and western medicine on ABO blood group incompatibility in maternal and neonatal children and the relationship between neonatal hemolysis and gestational age. Methods: A total of 314 ABO pregnant women (20-45 years old) with antibody titers≥1: 64 were studied. Among them, 246 pregnant women were treated with combination of TCM and western medicine (Yinchenhao decoction combined with 25% glucose solution, vitamins C, vitamin E, phenobarbital), 68 cases as a control, observe the changes in pregnant women IgG anti-A / B antibody titer and neonatal hemolysis. Results: Compared with the control group, the antibody titer in the treatment group was significantly lower than that in the control group (P <0.05). The incidence of neonatal hemolysis in the treatment group was significantly lower than that in the control group (P <0.05). The larger the pregnancy, the higher the incidence of neonatal hemolysis. Conclusion: The combination of Chinese and western medicine is satisfactory to reduce the IgG anti-A / B titer in pregnant women and prevent and treat neonatal hemolysis. Neonatal hemolysis may be positively correlated with pregnancy time.