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目的观察稳定性心绞痛患者发生急性冠状动脉综合征(ACS)前后血浆白细胞介素(IL)-18、IL-10水平的变化,探讨炎症在ACS发生中的作用及防治的新途径。方法检测211例稳定性心绞痛患者IL-18、IL-10水平变化,随访24个月,根据随访结果将患者分为ACS组(38例)及无ACS组(173例),并进行比较。结果 ACS组患者血浆IL-18水平及IL-18/IL-10比值明显高于无ACS组(P<0.01),血浆IL-10水平明显低于无ACS组(P<0.05);ACS组患者发生ACS后血浆IL-18水平及IL-18/IL-10比值明显高于ACS发生前(P<0.01),发生ACS后血浆IL-10水平明显低于ACS发生前(P<0.05)。结论稳定性心绞痛患者血浆IL-18、IL-10水平与ACS的发生密切相关,提示机体炎症在ACS发生中发挥重要作用,抗炎治疗可能是防治ACS的途径之一。
Objective To observe the changes of plasma interleukin (IL) -18 and IL-10 levels in patients with stable angina before and after acute coronary syndrome (ACS), and to explore the role of inflammation in the pathogenesis of ACS and a new way of prevention and treatment. Methods The levels of IL-18 and IL-10 in 211 patients with stable angina were detected and followed up for 24 months. According to the follow-up results, the patients were divided into ACS group (38 cases) and ACS group (173 cases). Results The plasma levels of IL-18 and IL-18 / IL-10 in patients with ACS were significantly higher than those without ACS (P <0.01), while the levels of plasma IL-10 were significantly lower than those without ACS (P <0.05) The level of plasma IL-18 and the ratio of IL-18 / IL-10 after ACS were significantly higher than those before ACS (P <0.01). The plasma levels of IL-10 after ACS were significantly lower than those before ACS (P <0.05). Conclusion The levels of plasma IL-18 and IL-10 in patients with stable angina are closely related to the occurrence of ACS, suggesting that inflammation plays an important role in the pathogenesis of ACS. Anti-inflammatory treatment may be one of the ways to prevent and treat ACS.