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《江苏省药品标准(1977年版)》422页所刊载的磺胺醋酰钠滴眼液处方中,用0.0836%浓度的山梨酸作为抑菌剂,我认为有些不妥。据文献记载:“山梨酸的防腐作用基于其未解离分子,故酸性水溶液中效果较大。据说pH值高于6.5时无效,而在pH值4.5时是最适宜的”。[沈阳药学院主编:药剂学,69页,人民卫生出版社,1980]本制剂规定pH值为8.0～9.8。制备时是先将山梨酸与等当量的氢氧化钠(0.0298%)中和,因此存在于制剂中的是已完全离子化的山梨酸钠盐,所以认为山梨酸在本制剂中的抑菌作用实属可疑。本制剂的另一处方所用的抑菌剂为0.025%尼泊金乙酯[北京医学院药学系:药剂学及制剂注释,179页,1976年]。尼泊金酯类作用的发挥也是基于其未解离的分子,溶
“Jiangsu Province, Drug Standards (1977 Edition)” 422 pages of sodium sulfacetamide sodium eye drops prescription, with 0.0836% concentration of sorbic acid as a bacteriostatic agent, I think some wrong. According to the literature: “Sorbic acid based on its anti-corrosion effect is not dissociated molecules, so the effect of acidic aqueous solution is larger .It is said that the pH value is higher than 6.5 when the invalid, but at pH 4.5 is the most suitable ”. [Shenyang Pharmaceutical College editor: Pharmacy, 69 pages, People’s Health Publishing House, 1980] The preparation provides pH value of 8.0 ~ 9.8. Sorbic acid was first neutralized with an equivalent amount of sodium hydroxide (0.0298%) in preparation, and therefore the sorbic acid salt present in the formulation was completely ionized. Therefore, the antibacterial effect of sorbic acid in the present formulation was considered It is suspicious. The antibacterial agent used in another prescription of this preparation is 0.025% ethylparaben [Department of Pharmacy, Beijing Medical College: Pharmacology and Pharmacological Notes, 179 pages, 1976]. The exertion of paraben esters is also based on their non-dissociated molecules, dissolved