为抢救急性肝功能衰竭,近年国内外对人工肝辅助装置展开了研究。这种装置的设计、试用和改进亟需通过大动物实验进行探索和检验,故制成大动物急性肝功能衰竭模型是此项研究工作中的一个重要内容。我们从1979年以来,用本地杂种家犬通过阻断肝脏血供产生急性肝功能衰竭,经过不断摸索。已获得初步成效。本文就实验方法作一简介,并结合前期摸索过程中的一些曲折进行讨论。 In order to rescue acute liver failure, artificial liver aids have been studied at home and abroad in recent years. The design, testing and improvement of such devices are urgently needed to be explored and tested through large animal experiments. Therefore, making a model of acute liver failure in large animals is an important part of this research. Since 1979, we have used local hybrid dogs to produce acute liver failure by blocking the blood supply of the liver, after continuous exploration. Has achieved initial success. In this paper, an introduction to the experimental method, combined with some twists and turns in the process of exploration.