原发性高血压的病因和发病机理至今尚未完全阐明,交感神经系统在发病中可能参与促发和维持血压升高的作用。在儿茶酚胺(CA)生物合成中,多巴胺—β—羟化酶(DBH)是促使多巴胺β位上羟化而形成去甲肾上腺素的调节酶,见图1。它在肾上腺素能交感神经系统的神经传递中起重要作用。DBH存在于肾上腺髓质嗜铬颗粒和交感神经未梢的贮存囊泡内。交感神经兴奋时DBH与去甲肾上腺素一起通过细泡外 The etiology and pathogenesis of essential hypertension has not yet been fully elucidated, the onset of sympathetic nervous system may be involved in the promotion and maintenance of elevated blood pressure. In catecholamine (CA) biosynthesis, dopamine-β-hydroxylase (DBH) is a regulatory enzyme that drives the hydroxylation of the β-position of dopamine to form norepinephrine, as shown in Figure 1. It plays an important role in the neurotransmission of the adrenergic sympathetic nervous system. DBH is present in adrenal medullary chromogranules and sympathetic neurons in the storage vesicles. Sympathetic nerve DBH and norepinephrine together through the thin foam outside