叶酰多聚谷氨酸合成酶(folyl-polyglutamate synthetase,FPGS)是近几年来研究比较多的肿瘤耐药靶酶之一。随着人们对其在基因组学和蛋白组学研究的逐渐深入,涉及FPGS(分胞浆型cFPGS和线粒体型mFPGS两种异构体)与肿瘤耐药的研究也越来越多。本文就FPGS结构、功能、生化特点及其与肿瘤耐药关系作一综述,并探讨其在临床的应用前景和意义。 Folyl-polyglutamate synthetase (folyl-polyglutamate synthetase, FPGS) is one of the most commonly studied tumor-resistant target enzymes in recent years. With the development of genomics and proteomics, more and more studies have been conducted on the drug resistance of FPGS (both cytoplasmic cFPGS and mitochondrial mFPGS). In this paper, the structure, function, biochemical characteristics of FPGS and its relationship with tumor resistance were reviewed, and its clinical application prospect and significance were discussed.