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目的观察奥曲肽联合奥美拉唑治疗门脉高压并上消化道出血术后再出血的疗效。方法将90例门脉高压症术后患者随机分为治疗组45例和对照组45例。治疗组给予奥曲肽联合奥美拉唑治疗,对照组单用奥美拉唑治疗。观察二组的止血效果。结果治疗组总有效率为93.3%,对照组为77.8%(P<0.01);止血时间治疗组为(21.76±5.35)h,对照组为(27.46±5.73)h(P<0.05);72h后再出血率治疗组为6.7%,对照组为22.2%,治疗组输血量为(1.67±0.54)U,对照组为(2.88±0.52)U,差异均有统计学意义(P<0.05)。结论奥曲肽联合奥美拉唑治疗门脉高压并上消化道出血术后再出血疗效显著,较单用奥美拉唑有止血速度快、输血量减少、早期再出血发生率低的特点。
Objective To observe the curative effect of octreotide combined with omeprazole on portal hypertension and rebleeding after upper gastrointestinal bleeding. Methods Ninety patients with portal hypertension were randomly divided into treatment group (45 cases) and control group (45 cases). The treatment group was treated with octreotide combined with omeprazole, and the control group with omeprazole alone. Hemostatic effect was observed in two groups. Results The total effective rate was 93.3% in the treatment group and 77.8% in the control group (21.76 ± 5.35) h in the control group and (27.46 ± 5.73) h in the control group (P <0.05) The rate of rebleeding was 6.7% in the treatment group and 22.2% in the control group. The blood transfusion volume was (1.67 ± 0.54) U in the treatment group and (2.88 ± 0.52) U in the control group, respectively, with statistical significance (P <0.05). Conclusion Omeprazole combined with omeprazole in the treatment of portal hypertension and upper gastrointestinal bleeding after rebleeding significantly, compared with single omeprazole fasting, blood transfusion reduced the incidence of early rebleeding low.