研究了厚皮树(Lannea coromandelica)树皮乙醇提取物(ELC)在麻醉状态下对狗和大鼠正常血压的降压作用,当ELC提取物静脉注射剂量为5～100mg/kg时,狗血压降低8.48％～65.8％,并呈量效关系;当静脉注射剂量为1～25mg/kg时,鼠血压降低4.21％～48.57％,呈量效相关。十二指肠内给药对狗和大鼠的血压、心率、呼吸没有影 The antihypertensive effect of the ethanol extract of the bark of the genus Lannea coromandelica (ELC) under normal anaesthesia on dogs and rats was studied. When the ELC extract was administered intravenously at a dose of 5 to 100 mg/kg, the dog’s blood pressure was measured. Decrease 8.48% to 65.8%, and showed a dose-effect relationship; when the intravenous dose of 1 ~ 25mg/kg, the blood pressure decreased by 4.21% to 48.57%, showing dose-effect correlation. Intraduodenal administration has no effect on blood pressure, heart rate, and breathing in dogs and rats