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目的研究降钙素原(PCT)含量对早期诊断儿童脓毒血症的应用价值。方法 36例脓毒血症患儿作为脓毒血症组,50例同期住院的非脓毒血症患儿作为对照组。两组患儿均于住院24 h内进行PCT、C-反应蛋白(CRP)、白细胞(WBC)计数测定,比较两组的测定结果。结果脓毒血症组PCT、CRP水平明显高于对照组,两组比较差异具有统计学意义(P<0.01),两组WBC计数比较差异无统计学意义(P>0.05),脓毒血症患儿中PCT的敏感度、特异性及约登指数均高于CRP和WBC计数。结论 PCT含量测定在早期诊断儿童脓毒血症时明显优于CRP和WBC计数,能更真实的反映临床情况,具有很好的临床应用价值。
Objective To study the value of procalcitonin (PCT) in the early diagnosis of sepsis in children. Methods Thirty-six children with sepsis were enrolled as sepsis group and 50 asymptomatic non-sepsis children as control group. Two groups of children were hospitalized within 24 h of PCT, C-reactive protein (CRP), white blood cell (WBC) count determination, the results of the two groups were compared. Results The levels of PCT and CRP in sepsis group were significantly higher than those in control group (P <0.01). There was no significant difference in WBC count between two groups (P> 0.05), sepsis PCT in children with sensitivity, specificity and Youden index were higher than the CRP and WBC count. Conclusion The determination of PCT content in early diagnosis of sepsis in children was significantly better than the CRP and WBC count, can more truly reflect the clinical situation, has good clinical value.