本文提出了差示一线性组合导数光谱法用于测定混合组分体系的基本原理和实验方法。并试用本法消除了扑尔敏、溴化丙胺太林、灵芝粉及附加剂之间的相互干扰,从而分别测定了扑咳灵片巾扑尔敏和溴化丙胺太林的含量,其平均回收率分别为100.2±1.49％(CV)和99.89±1.03％(CV)。其精密度、准确度均好。 In this paper, the basic principles and experimental methods for the determination of mixed components by differential-linear combination derivative spectroscopy are proposed. And try this method to eliminate chlorpheniramine, promethazine bromide, Ganoderma lucidum powder and additives interfere with each other, which were measured fluticasin chlorpheniramine chlorpheniramine and propranolol content, the average recovery Rates were 100.2 ± 1.49% (CV) and 99.89 ± 1.03% (CV), respectively. Its precision, accuracy are good.