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对弹性酶所致大鼠肺动脉高压模型及慢性肺心病患者的研究证实,和对照组比较,全血5-HT、Ach含量升高,红细胞AehE活性降低或不变。这些变化可能在肺心病的发病中起促进作用。
Elastase-induced pulmonary hypertension in rats and patients with chronic cor pulmonale studies confirmed that, compared with the control group, the whole blood 5-HT, Ach content increased erythrocyte AehE activity decreased or unchanged. These changes may play a role in the pathogenesis of pulmonary heart disease.