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脂皮质素-1（LC－1）是36．7ku的蛋白质，它是LC超家族（LC－1，LC－2，LC-5等），也称为粘附蛋白超家族的成员之一。起初，将其作为糖皮质激素抗炎作用的“第二信使”，后来发现它在细胞生长调节与分化、白细胞迁移、中枢神经系统（CNS）对细胞因子的反应、神经内分泌和神经变性中起重要作用。应用免疫中和战略以及用高纯度或重组LC－1，抑或用它的生物活性肽片段模拟类固醇的作用，已证明了LC－1在介导糖皮质激素的诱导中的作用。曾认为LC-1的作用模式可能主要是抑制前列腺素（PG）的形成，现在看来，它可改变多种细胞功能。本文还简述了LC-1的性质，各种作用与临床的关系，以及可能的作用机制。
Lipid-1 (LC-1) is a 36.7ku protein that is a member of the LC superfamily (LC-1, LC-2, LC-5, etc.), also known as the adherent protein superfamily. Initially, it was used as a “second messenger” for the anti-inflammatory effects of glucocorticoids and was later found to play a role in cell growth regulation and differentiation, leukocyte migration, CNS response to cytokines, neuroendocrine and neurodegeneration Important role. The role of LC-1 in mediating the induction of glucocorticoids has been demonstrated using immunological neutralization strategies and the role of high purity or recombinant LC-1, or mimicking steroids with its bioactive peptide fragments. It has been suggested that the mode of action of LC-1 may mainly inhibit the formation of prostaglandin (PG), which now appears to alter a wide variety of cellular functions. This article also briefly described the nature of LC-1, the various roles and clinical relationship, and possible mechanism of action.