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HBsAg 携带者的临床过程可因年龄而异。有关儿童慢性 HBsAg 携带者 HBeAg/抗-HBe 的长期转换以及临床特征了解甚少。本文观察55例 HBsAg 阳性日本儿童(男26、女39),年龄0～15岁(平均7.8±4.0岁),并随访12～115个月。48例儿童的家庭成员有 HBV 携带者,其中45例的母亲为HBV 携带者。随访期间每1～6个月进行临床和生化评价(SGPT 30 KU 以上为异常),并对9例 SGPT 异常者进行一次或多次肝活检。
The clinical course of HBsAg carriers can vary with age. Little is known about the long-term conversion and clinical features of HBeAg / anti-HBe in children with chronic HBsAg carriers. In this paper, 55 cases of HBsAg-positive Japanese children (male 26, female 39) aged 0-15 years (mean 7.8 ± 4.0 years) were observed and followed up for 12 to 115 months. 48 cases of children with family members of HBV carriers, of which 45 cases of mothers for HBV carriers. Clinical and biochemical evaluations were performed every 1 to 6 months during follow-up (abnormalities above SGU 30 KU), and one or more liver biopsies were performed on 9 patients with abnormal SGPT.