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目的 探讨TNF -α与IgA肾病的临床病理联系。方法 检测 5 0例IgA肾病患者血、尿TNF -α的浓度及肾组织TNF-α的表达 ,10例肾小球微小病变型患者及 10例健康人作为阴性对照 ,并选出缓解的患者作自身对照。结果 IgA肾病患者血、尿TNF -α水平均明显高于微小病变患者和正常人 ,与尿蛋白及病理的严重程度正相关 ;TNF -α阳性反应主要表达于肾近曲小管上皮细胞胞浆内 ,在单核巨噬细胞和淋巴细胞浸润较多的间质也有表达。结论 TNF -α参与了IgA肾病患者肉眼血尿、蛋白尿的发生 ,并与肾组织病变程度相关 ,是病情加重的一个重要因素。
Objective To investigate the clinicopathological relationship between TNF-α and IgA nephropathy. Methods The levels of blood and urine TNF-α and the expression of TNF-α in renal tissue were detected in 50 patients with IgA nephropathy. Ten patients with glomerulonephritis and 10 healthy controls were selected as negative control and the patients with remission were selected Self-control. Results The levels of blood and urine TNF-αin patients with IgA nephropathy were significantly higher than those in patients with mild and normal controls, and positively correlated with the urinary protein and pathological severity. The positive expression of TNF-α was mainly expressed in the cytoplasm of renal proximal tubule epithelial cells , In mononuclear macrophages and lymphocytes infiltration more interstitial expression. Conclusion TNF-α is involved in the gross hematuria and proteinuria in patients with IgA nephropathy, and is associated with the severity of renal tissue disease. It is an important factor in aggravating the disease.