本文报告3例,孤立性肺组织细胞增生症,随访3年余并对其表现、治疗和预后进行讨论。病例病例12月,男,临床诊断支气管肺炎。持续咳嗽、呼吸困难,伴食纳少、呕吐和体重减轻。体查:气促,无发绀,双上肺闻捻发音。胸片见双肺模糊的浸润,以左肺为著。给抗生素和胸部理疗后症状见轻。4个月时,呼吸困难加重,伴喘鸣和发绀,胸片见左胸细小网点状浸润。同位素肺扫描示灌注正常,但右肺通气减少。左下肺活检见肺泡和围绕细支气管末端之间组织细胞呈弥漫性增生,故确诊为肺组织胞细增生症X。予强的松龙、长春碱和鬼臼乙叉甙(etoposide)(VP16)一疗程后明显好转,激素用至患儿15个月。3岁时仍无症状,胸片见上、中部肺野有网状影,其它器官部位无组织细胞增生。 This article reports 3 cases of isolated pulmonary histiocytosis, followed up for more than 3 years and its performance, treatment and prognosis are discussed. Case cases December, male, clinical diagnosis of bronchial pneumonia. Continuous cough, difficulty breathing, poor appetite, vomiting and weight loss. Physical examination: shortness of breath, no cyanosis, double lung smelling pronunciation. Chest radiography see infiltration of the lungs to the left lung. Give antibiotics and chest treatment after the symptoms see light. 4 months, increased breathing difficulties, with wheezing and cyanosis, small chest chest Xinyi see punctate infiltration. Isotope lung scan showed normal perfusion, but decreased right lung ventilation. Left lower lung biopsy showed alveolar and surrounding bronchioles tissue cells showed diffuse hyperplasia, it was diagnosed as lung tissue cell hyperplasia X. Prednisolone, vinblastine and etoposide (VP16) were significantly improved after a course of treatment, and hormones were administered to children for 15 months. 3-year-old still asymptomatic, chest X-ray see, the middle of the lung field have a net shadow, other parts of the tissue without cell proliferation.