寻找高效低毒的根治间日疟药物是当前抗疟药研究中的重要课题。自伯喹问世20年以来,尚无可以代替它的理想新药。Coatney(1953)曾指出,某些5-取代-6-甲氧基-8-氨基喹啉类化合物,比相应的5位上无取代基的化合物具有更强的抗疟作用和更低的毒性反应。近年来,Chen等(1977)和Tanabe等(1978)报道了某些5-取代伯喹衍生物的毒性明显低于伯喹,其中个别5-取代 Looking for efficient and low-toxic vivax malaria drug is an important issue in the current study of anti-malarial drugs. Since the advent of beequi 20 years ago, there is no ideal new drug to replace it. Coatney (1953) has pointed out that certain 5-substituted-6-methoxy-8-aminoquinolines have stronger anti-malarial effects and lower toxicity than the corresponding compounds without substituents at the 5-position reaction. In recent years, Chen et al. (1977) and Tanabe et al. (1978) reported that certain 5-substituted primaquine derivatives are significantly less toxic than primaquine, with individual 5-substituted