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The C-H and C-C bonds are abundant in organic compounds,yet generally inert in chemical transformations.Therefore,direct functionalization of inert chemical bonds remains challenging.The fluorine-containing compounds are of special interest for their uses in medicinal chemistry.Direct fluorination of C-H and C-C bonds undoubtedly represents one of the most ideal and attractive approaches to incorporate fluorine atom into complex molecules.Herein,we summarize the recent advances in radical-mediated C-H and C-C bond fluorination.Three types of transformations are discussed:(1)direct C-H abstraction/fluorination of alkanes;(2)decarboxylative fluorination of alkyl carboxylic acids;(3)ring-opening fluorination.
The CH and CC bonds are abundant in organic compounds, yet generally inert in chemical transformations. Therefore, direct functionalization of inert chemical bonds remains challenging. The fluorine-containing compounds are of special interest for their uses in medicinal chemistry. Direct fluorination of CH and CC bonds undoubtedly one of the most ideal and attractive approaches to incorporate fluorine atom into complex molecules. Herein, we summarize the recent developments in radical-mediated CH and CC bond fluorination. Three types of transformations are discussed: (1) direct CH abstraction / fluorination of alkanes; (2) decarboxylative fluorination of alkyl carboxylic acids; (3) ring-opening fluorination.