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本文描述一种临床病理学上特殊亚型的胆囊炎——广泛钙化型,临床文献称之为“瓷化胆囊”。本作者提出了玻璃样变性胆囊炎(HC)的命名,其特征为密度增高、细胞数量减少、纤维化及玻璃样变,使胆囊壁变成相对薄而均一的带状。病变广泛破坏大部分正常胆囊结构,一些病例表现为钙化。为了确定HC在临床病理学上的共性特征,作者用组织病理学方法系统分析了4 231例胆囊切除标本(其中606例为癌),除此之外,还在数据库中进行了针对性的文献检索,共找出96例HC,占胆囊切除标本的1.6%。HC患者比一般胆囊炎患者年长近10岁(56∶47,P<0.05),提示HC可能是长期慢性损伤所致的并发症。2/3病例中发现不同数量和程度的钙化。另外,10例呈现显著弥漫性钙化,可归为“完全瓷化”性胆囊炎。38例HC患者伴有
This article describes a clinicopathologically distinctive subtype of cholecystitis - a widespread calcification known as “porcelain gallbladder” in clinical literature. The authors propose nomenclature for hyaline degenerative cholecystitis (HC) characterized by increased density, reduced cell numbers, fibrosis, and glass-like changes that turn the gallbladder wall into a relatively thin and uniform band. Lesions extensively destroy most of the normal gallbladder structures, with calcification in some cases. In order to determine the common clinical and pathological characteristics of HC, the authors systematically analyzed 4 231 cases of cholecystectomy (including 606 cases of cancer) by using histopathological methods. In addition, we also conducted targeted literature in the database Retrieved, a total of 96 cases of HC, accounting for 1.6% of cholecystectomy specimens. HC patients older than the general cholecystitis nearly 10 years old (56:47, P <0.05), suggesting that HC may be caused by long-term chronic injury complications. Different numbers and degrees of calcification were found in 2/3 of the cases. In addition, 10 cases showed significant diffuse calcification, can be classified as “completely porcelain ” cholecystitis. 38 cases of HC patients