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肾的全部功能是维持机体稳态。调节体液量和电解质组成是肾的主要功能之一,肾通过对水和电解质的精细调节,维持了正常的心血管功能。 七十年代以来,逐渐认识到肾内存在多个与水钠调节有关的体液系统。有的具有血管和抗利钠效应,称之为升压系统(Vasopressor System),如肾素-血管紧张素系统。有的具有扩血管和利钠利尿效应,称之为减压系统(Vasodepressor System),如前列腺素系统和激肽释放酶-激肽系统。本文局限于讨论作为局部激素的贤内体液系统。 肾内的肾素-血管紧张素系统(RAS) 一、肾内RAS的定位
The full function of the kidney is to maintain the body’s homeostasis. Regulation of body fluid volume and electrolyte composition is one of the main functions of the kidney, which regulates normal cardiovascular function through fine regulation of water and electrolytes. Since the 1970s, it has been gradually realized that there are several body fluid systems in the kidney that are related to water and sodium regulation. Some have vasoactive and natriuretic effects, called the Vasopressor System, such as the renin-angiotensin system. Some have vasodilator and natriuretic effects, called the Vasodepressor System, such as the prostaglandin system and the kallikrein-kinin system. This article is limited to discussing the body’s fluid system as a partial hormone. Renin-renin-angiotensin system (RAS) 1. Renal RAS localization