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抗痨肼和异烟肼为临床常用的抗痨药物,一般治疗剂量很少发生副作用。本文报道1例分别对以上药物发生不同的药物反应。患者(住院号1623)女性,21岁,工人。于1962年9月7日由某职工医院因“传染性肝炎”转来我院。患者于1962年7月30日因左侧结核性胸膜炎住某职工医院治疗,当时口服P.A.S.2克,每日三次,肌注鏈霉素0.5克,每日二次。8月11日体温正常,胸膜炎症吸收。8月18日停用P.A.S.,改用抗痨肼口服,0.2克每日三次,次日体温逐渐升高达39.8℃,第五日全身出现荨麻疹,出疹后二天停用抗痨肼并用脱敏治疗,随之皮疹逐渐消退,体温下降。8月29日加用口服异烟肼,
Anti-tuberculosis and isoniazid are clinically commonly used anti-tuberculosis drugs, the general treatment dose rarely occur side effects. This article reports a case of different drug reactions to the above drugs. Patient (hospital number 1623) Female, 21 years old, worker. In September 7, 1962 by a staff hospital due to “infectious hepatitis” transferred to our hospital. Patients on July 30, 1962 due to left tuberculous pleurisy live in a hospital for treatment, when oral P.A.S.2 grams, three times a day, intramuscular streptomycin 0.5 grams twice daily. August 11 normal body temperature, pleural inflammation absorption. August 18 disable PAS, switch to oral administration of anti-tuberculosis, 0.2 grams three times a day, the next day the temperature gradually increased 39.8 ℃, the fifth day urticaria body, disabled two days after rash anti-hydrazine and desensitization Treatment, followed by rash subsided, body temperature decreased. August 29 plus oral isoniazid,