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作者用流式细胞仪分析５０例原发性骨髓增生异常综合征（ＭＤＳ）患者和１２例健康献血员的骨髓细胞周期分布。结果显示：Ｓ＋Ｇ＿２Ｍ期细胞比例在ＭＤＳ明显低于正常对照（Ｐ＜０．０２）；在ＲＡＥＢ和ＲＡＥＢ－ｔ组明显低于ＲＡ组和ＲＡＳ组（均Ｐ＜０．０１）；与骨髓原始粒细胞比例呈负相关（ｒ＝－０．６３，Ｐ＜０．００１）；与骨髓幼稚红细胞呈正相关（ｒ＝０．４８，Ｐ＜０．０１）。还研究了ＭＤＳ向急性白血病（ＡＬ）演变过程中Ｓ＋Ｇ＿２Ｍ期细胞比例的动态变化及其与治疗反应和预后的关系。
The authors used flow cytometry analysis of 50 patients with primary myelodysplastic syndrome (MDS) patients and 12 healthy blood donors bone marrow cell cycle distribution. The results showed that the proportion of cells in S phase was significantly lower in MDS than that in normal controls (P <0.02), significantly lower in RAEB and RAEB-t groups than in RA and RAS groups (all P <0.01) (R = -0.63, P <0.001). There was a positive correlation between the ratio of lymphocytes and erythrocytes in bone marrow (r = 0.48, P <0.01). The dynamic changes of the proportion of cells in S + G2-M phases during the progression of MDS to acute leukemia (AL) were also studied, and their relationship to response and prognosis was also investigated.