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用流式细胞仪对尿毒症患者血小板糖蛋白(GP)Ⅰ_b和GPⅡ_b/Ⅲ_a进行分析,同时测定了患者血小板聚集率及血浆纤维蛋白原含量。结果显示尿毒症组与对照组相比,血小板膜GPⅠb、GPⅡ_b/Ⅲ_a和血浆纤维蛋白原含量均无明显差异,而尿毒症组血小板计数和血小板聚集率均极显著低于对照组(P<0.01;P<0.01)。提示尿毒症患者血小板功能缺陷并非血小板膜糖蛋白变化所致,而可能与血小板数量减少及活性改变有关。
Platelet glycoprotein (GP) Ⅰ_b and GPⅡ_b / Ⅲ_a were analyzed by flow cytometry in patients with uremia, and the platelet aggregation rate and plasma fibrinogen level were also determined. The results showed that platelet membrane GPⅠb, GPⅡ_b / Ⅲ_a and plasma fibrinogen content had no significant difference between uremia group and control group, but uremic group platelet count and platelet aggregation rate were significantly lower than the control group (P <0.01 ; P <0.01). Prompt uremic patients with platelet function defects is not caused by changes in platelet glycoprotein, and may be related to reduced platelet count and changes in activity.