论文部分内容阅读
白血病抑制因子(LIF)是1986年澳大利亚墨尔本Water和Eliza学院临床研究所的Metcalf和他的同事们首先确认的。LIF是一种有6种白细胞介素的多向性的细胞活素,它对许多不同类细胞起作用,它的活性不受连锁细胞限制。许多细胞有LIF的受体,包括神经细胞、巨核细胞、巨噬细胞、脂肪细胞、肝细胞、上皮细胞、成肌细胞和肾、乳腺上皮细胞,以及来自这些组织的肿瘤细胞系列。每一种类的哺乳动物都有它自己的LIF,而老鼠、人类、羊、猪和大老鼠的LIF的核苷酸链已命名。
Leukemia inhibitory factor (LIF) was first confirmed by Metcalf and his colleagues at the Clinical Research Institute, Water and Eliza College, Melbourne, Australia in 1986. LIF is a multi-directional cytokine with six interleukins that acts on many different cell types and its activity is not restricted by the chain cells. Many cells have LIF receptors, including neurons, megakaryocytes, macrophages, adipocytes, hepatocytes, epithelial cells, myoblasts and kidneys, mammary epithelial cells, and tumor cell lines from these tissues. Each species of mammal has its own LIF, whereas the nucleotide chain of LIF in mice, humans, sheep, pigs and rats has been named.