作者报告了一伴有EB病毒及克隆性DNA重排,并有Castleman氏病某些组织学特点的持续弥散性淋巴组织增生病例。患者,男,54岁。7年来先后发生颏下及颈部淋巴结、泪腺及腮腺、左右眼窝、纵膈和硬腭的淋巴组织增生。常规血化学及全血细胞计数均在正常范围,无免疫缺陷的证据。本文对患者进行了组织及免疫组织学、流式细胞仪、基因重排及 The authors report a case of persistent disseminated lymphoid hyperplasia associated with Epstein-Barr virus and clonal DNA rearrangements and some histological features of Castleman’s disease. Patient, male, 54 years old. Seven years have occurred under the chin and neck lymph nodes, lacrimal gland and parotid gland, about the orbital, mediastinal and palate of the lymphatic tissue hyperplasia. Routine blood chemistry and complete blood count were in the normal range, with no evidence of immunodeficiency. In this paper, we performed histological and immunohistological studies, flow cytometry, gene rearrangement and