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AIM:To determine the risk of second primary malignancy(SPM) and survival of patients with essential thrombocythemia(ET).METHODS:We identified all patients with ET diagnosed during 2001 to 2011 from the Surveillance,Epidemiology and End Results(SEER) 18 database.Actuarial and relative survival methods were used to calculate the survival statistics.We utilized the SEER 13 database to calculate SPM.We used multiple primary standardized incidence ratio(SIR) session of the SEER*Stat software(version 8.1.5) to calculate SIR and excess risk of SPM for ET patients.RESULTS:Age standardized five-year cause-specific survival was greater for patients < 50 years vs those ≥ 50 years(99.4% vs 93.5%,P < 0.01).Five-year causespecific survival was lower for men vs women(70.2% vs 79.7%).A total of 201 patients(2.46%) developed SPM at a median age of 75 years.SPMs occurred at an observed/expected(O/E) ratio of 1.26(95%CI:1.09-1.45,P = 0.002) with an absolute excess risk(AER) of 37.44 per 10000 population.A significantly higher risk was noted for leukemia(O/E 3.78; 95%CI:2.20-6.05,P < 0.001; AER 11.28/10000).CONCLUSION:ET patients have an excellent causespecific five-year survival but are at an increased risk of SPM,particularly leukemia,which may contribute to excess deaths.
AIM: To determine the risk of second primary malignancy (SPM) and survival of patients with essential thrombocythemia (ET). METHODS: We identified all patients with ET diagnosed during 2001 to 2011 from the Surveillance, Epidemiology and End Results (SEER) 18 database . Actuarial and relative survival methods were used to calculate the survival statistics. We utilized the SEER 13 database to calculate SPM. We used multiple primary normal incidence incidence (SIR) session of the SEER * Stat software (version 8.1.5) to calculate SIR and excess risk of SPM for ET patients .RESULTS: Age standardized five-year cause-specific survival was greater for patients <50 years vs those ≥ 50 years (99.4% vs 93.5%, P <0.01) A total of 201 patients (2.46%) developed SPM at a median age of 75 years. SPMs occurred at an observed / expected (O / E) ratio of 1.26 (95% CI: 1.09-1.45, P = 0.002) with an absolute excess risk (AER) of 37.44 per 10000 populatio CONCLUSION: ET patients have an excellent causes specific five-year survival but are at an increased risk (O / E 3.78; 95% CI: 2.20-6.05, P <0.001; AER 11.28 / of SPM, particularly leukemia, which may contribute to excess deaths.