免疫排斥反应是角膜移植失败的主要原因[1] 。目前 ,临床上防治排斥主要依靠皮质类固醇激素和环孢霉素A ,这些药物长期使用会产生较严重的毒、副作用。最近研究显示 ,在高危角膜移植中 ,尽管术后全身和局部应用常规免疫抑制剂 ,仍有 4 9%的排斥反应不可逆转[2 ] 。近年来 ,新药 Immune rejection is the main reason for the failure of corneal transplantation [1]. At present, the main clinical prevention and treatment of rejection rely on corticosteroids and cyclosporin A, these drugs will have more serious long-term use of toxic and side effects. Recent studies have shown that in high-risk keratoplasty, despite the systemic and local application of conventional immunosuppressive agents after surgery, 49% of the rejection remains irreversible [2]. In recent years, new drugs