钙通道阻滞剂(CCB)最初用于治疗心绞痛和室上性心律失常。后来证明,CCB有明显的抗高血压作用。CCB降压效果与常用降压药相似,联合治疗时效果增强,副作用轻,停药后消失;对血脂、血糖、血钾的不良影响小,对多种伴随病有治疗作用,宜列为一线抗高血压药。 CCB药理学心肌和血管平滑肌细胞钙离子流,涉及三种机理:(1)电压依赖性通道,此通道闸门的开关受控于电压梯度变化。CCB均结合于 Calcium channel blockers (CCBs) were originally used to treat angina pectoris and supraventricular arrhythmias. Later proved that CCB has obvious antihypertensive effect. CCB antihypertensive effect is similar to the commonly used antihypertensive drugs, combined treatment effect is enhanced, side effects light, disappear after drug withdrawal; adverse effects on blood lipids, blood glucose, potassium is small, for a variety of concomitant diseases have therapeutic effect, should be listed as the first line Antihypertensive drugs. There are three mechanisms involved in CCB pharmacological cardiomyocyte and vascular smooth muscle cell Ca2 + currents: (1) Voltage-dependent channels whose switches are controlled by voltage gradient changes. CCB are combined in