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目的:比较肥胖与非肥胖多囊卵巢综合征(PCOS)患者血清肿瘤坏死因子-α(TNF-α)水平的差异。方法:55例PCOS患者,根据体质量指数(BMI)分为肥胖组(BMI>25,n=31)和非肥胖组(BMI≤25,n=24);同期选择50例非PCOS育龄妇女,分为肥胖对照组(BMI>25,n=25)和非肥胖对照组(BMI≤25,n=25)。应用酶联免疫吸附法(ELISA)测定血清TNF-α的含量,分析TNF-α与胰岛素抵抗指数(HOMA-IR)的相关性。结果:PCOS肥胖组与PCOS非肥胖组的TNF-α水平分别显著高于其相应的对照组(P<0.01),PCOS非肥胖组的TNF-α水平也显著高于肥胖对照组(P<0.05)。PCOS肥胖组与PCOS非肥胖组之间的TNF-α水平无显著差异(P>0.05)。PCOS组TNF-α与HOMA-IR呈显著正相关(P<0.05)。结论:肥胖与非肥胖PCOS患者的血清TNF-α水平均升高,可能存在肥胖以外升高TNF-α的途径;TNF-α与PCOS的IR发生有密切联系。
Objective: To compare the difference of serum tumor necrosis factor-α (TNF-α) between obese and non-obese patients with polycystic ovary syndrome (PCOS). Methods: Fifty-five patients with PCOS were divided into obesity group (BMI> 25, n = 31) and non-obese group (BMI≤25, n = 24) according to body mass index Divided into obese control group (BMI> 25, n = 25) and non-obese control group (BMI≤25, n = 25). Serum TNF-α levels were determined by enzyme-linked immunosorbent assay (ELISA), and the correlation between TNF-α and insulin resistance index (HOMA-IR) was analyzed. Results: The levels of TNF-α in PCOS obese group and PCOS non-obese group were significantly higher than those in control group (P <0.01), and those in PCOS non-obese group were also significantly higher than those in obese control group (P <0.05) ). There was no significant difference in TNF-α level between PCOS obese group and PCOS non-obese group (P> 0.05). There was a significant positive correlation between TNF-α and HOMA-IR in PCOS group (P <0.05). CONCLUSION: Serum levels of TNF-α are elevated in both obese and non-obese patients with PCOS. There may be a pathway of increasing TNF-α other than obesity. There is a close relationship between TNF-α and IR of PCOS.