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目的探讨电刺激大鼠缰核(Hb)对呼吸运动的影响及阻塞性睡眠呼吸暂停综合征(OSAS)的可能机制。方法电刺激大鼠Hb相应部位,同一刺激位点调整刺激参数,分别给予70μA或90μA电流强度,对照组给予同样电流刺激,记录刺激前后呼吸频率、胸廓运动幅度的数值。结果电刺激Hb可以引起呼吸频率加快、呼吸幅度加大(P<0.05),同一刺激位点刺激强度增加可引起呼吸频率增加更明显(P<0.05),呼吸幅度变化不大(P<0.05)。电刺激内侧缰核(MHb)内侧部出现呼吸明显减慢甚至呼吸暂停,同时呼吸幅度变浅(P<0.05)。电刺激MHb外侧部(L:0.3)和外侧缰核(L:0.5)均出现刺激过程中呼吸加快,但电刺激时胸廓运动幅度可有幅度变大或变小两种改变。结论Hb可能参与呼吸运动的调节及OSAS的发生。
Objective To investigate the effect of electrical stimulation of habenula (Hb) on respiratory activity and the possible mechanism of obstructive sleep apnea syndrome (OSAS). Methods The corresponding sites of Hb in rats were electrically stimulated. The stimulation parameters were adjusted by the same stimulation site, and the currents of 70μA or 90μA were given respectively. The control group was given the same current stimulation, and the values of respiratory rate and amplitude of thoracic motion were recorded before and after stimulation. Results The electrical stimulation of Hb could cause the respiratory rate to increase and the respiratory rate to increase (P <0.05). The increase of stimulation intensity at the same stimulation site could cause more obvious increase of respiratory frequency (P <0.05) and little change of respiratory amplitude (P <0.05) . Electrical stimulation of the medial part of the medial habenular nucleus (MHb) significantly slowed down or even apnea, breathing amplitude at the same time shallow (P <0.05). Electrical stimulation of the lateral part of MHb (L: 0.3) and the lateral habenular nucleus (L: 0.5) occurred in the process of stimulation of respiratory acceleration, but the amplitude of electrical stimulation of thoracic motion amplitude can be larger or smaller two changes. Conclusion Hb may be involved in the regulation of respiration and the occurrence of OSAS.