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HBsAg和HBsAg阳性母亲的96～100%婴儿可致乙型肝炎病毒感染,其中85～100%能成为HBsAg慢性携带者。本文调查每月给HBeAg阳性母亲的新生儿以乙型肝炎免疫球蛋白(HBIg),能否预防乙型肝炎和变为HBsAg慢性携带者。40例慢性携带妇女的44例婴儿,妊娠第三期患急性乙型肝炎母亲的5例婴儿作为研究对象。40例携带者中10例HBeAg(+),25例抗HBe(+)。分娩48小时内婴儿肌注HBIg 0.5ml/kg,继之0.16ml/kg/每月,共6个月。HBsAg携带母亲的21例婴儿应用上述治疗。1例每月注射HBIg共26个月。3例于出生第4～5天方注射HBIg。另20例未
Between 96 and 100% of infants with HBsAg and HBsAg positive mothers have hepatitis B virus infection, 85-100% of whom become chronic HBsAg carriers. This article investigates whether monthly immunization of HBeAg-positive mothers with hepatitis B immunoglobulin (HBIg) can prevent hepatitis B and become chronic carriers of HBsAg. Forty-four infants with chronic carriers of women and five infants with third-trimester mothers with hepatitis B were enrolled in this study. Of the 40 carriers, 10 were HBeAg (+) and 25 were anti-HBe (+). Infants intramuscular injection of HBIg 0.5ml / kg within 48 hours after childbirth, followed by 0.16ml / kg / month for a total of 6 months. The 21 HBsAg-bearing mothers used the above treatment. One patient received HBIg every month for 26 months. 3 cases were born in the first 4 to 5 days HBIg injection. Another 20 cases did not