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目的探讨急性冠脉综合征(ACS)患者血清肌钙蛋白(cTnⅠ)和高敏C-反应蛋白(hs-CRP)测定的临床意义。方法采用化学发光免疫分析法测定所有ACS患者(ACS组)的cTnⅠ含量,采用微粒增强免疫透射比浊法测定hs-CRP含量,同时随机取30例门诊健康体健者作为对照组。结果ACS组的cTnⅠ和hs-CRP含量均显著高于对照组(P<0.01),ACS组中,急性心肌梗死(AMI)组的cTnⅠ、hs-CRP水平均显著高于不稳定型心绞痛(UAP)组(P<0.01)。结论心肌损伤特异性指标cTnⅠ和机体炎症急相期敏感性指标hs-CRP含量升高与ACS的严重程度密切相关,对ACS早期诊断及预后均具有重要临床价值。
Objective To investigate the clinical significance of serum cTnI and hs-CRP in patients with acute coronary syndrome (ACS). Methods Chemiluminescent immunoassay was used to determine the cTnI level in all patients with ACS. The level of hs-CRP was determined by microparticle-enhanced immunoturbidimetry. Meanwhile, 30 outpatients with healthy body weight were randomly selected as the control group. Results The levels of cTnⅠ and hs-CRP in ACS group were significantly higher than those in control group (P <0.01). In ACS group, the levels of cTnⅠ and hs-CRP in AMI group were significantly higher than those in unstable angina pectoris group ) Group (P <0.01). Conclusions The increase of hs-CRP, a specific marker of myocardial injury, and sensitivity index of acute phase of acute inflammation are closely related to the severity of ACS. It has important clinical value in early diagnosis and prognosis of ACS.