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用提纯的Ｓ．ｍｕｔａｎｓＭＴ６Ｒ（血清型ｃ）表面蛋白Ｐ１加弗氏佐剂对ＢＡＬＢ／Ｃ大鼠行腮腺区和背部皮下注射免疫，得到含高效价抗Ｓ．ｍｕｔａｎｓ（血清型ｃ）表面蛋白Ｐ１抗体的大鼠血清和唾液，观察此Ｐ１抗体对已粘附到唾液包被的羟磷灰石微珠（Ｓ－ＨＡ）表面的各型变形链球菌的影响。结果发现抗变链ｃ型表面蛋白Ｐ１抗体对已粘附到Ｓ－ＨＡ表面的Ｓ．ｍｕｔａｎｓＭＴ６Ｒ，Ｓ．ｍｕｔａｎｓＬＭ７，Ｓ．ｍｕｔａｎｓＯＭＺ１７５菌株有一定的解脱粘附作用（Ｐ＜０．０５），而对Ｓ．ｃｒｉｃｅｔｕｓＡＨＴ，Ｓ．ｒａｔｔｕｓＢＨＴ，Ｓ．ｓｏｂｒｉｎｕｓＯＭＺ１７６，Ｓ．ｓｏｂｒｉｎｕｓ６７１５菌株的解脱作用不明显（Ｐ＞０．０５）。
Purified S. MutansMT6R (serotype c) surface protein P1 plus Freund's adjuvant was immunized subcutaneously in the parotid gland area and back in BALB / c rats, resulting in high titre anti-S. mutans (serotype c) surface protein P1 antibody in rat serum and saliva to observe the effect of this P1 antibody on each type of Streptococcus mutans that has adhered to the surface of saliva-coated hydroxyapatite beads (S-HA) . As a result, it was found that the anti-chain c-surface protein P1 antibody had adhered to the S-HA surface. mutansMT6R, S. mutansLM7, S. MutansOMZ175 strain has a certain role in the adhesion and detachment (P <0.05), while S. cricetusAHT, S. rattusBHT, S. sobrinusOMZ176, S. The release of sobrinus6715 strain was not obvious (P> 0.05).