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本实验测定了不同浓度ＨＬ－ＲＮＡ在离体与活体条件下对Ｘ射线照射小鼠脾细胞丝裂原诱导的增殖反应的影响。结果表明，在离体条件下，ＨＬ－ＲＮＡ对照后脾细胞ＣｏｎＡ诱导的增殖反应有明显的抑制作用，并且随ＨＬ－ＲＮＡ浓度的增加抑制作用增强。而不同浓度的ＨＬ－ＲＮＡ对活体照后小鼠脾细胞ＣｏｎＡ和ＬＰＳ诱导的增殖反应有促进作用，当ＨＬ－ＲＮＡ浓度大于６．２５ｍｇ／ｋｇ体重时，照射组与对照组有明显差异。同时测定ＨＬ－ＲＮＡ诱导血清照后小鼠脾细胞ＣｏｎＡｆｏＬＰＳ诱导的增殖反应也明显增强。提示，ＨＬ－ＲＮＡ在体内外对照射小鼠脾细胞的增殖反应有不同作用。
The present study determined the effect of different concentrations of HL-RNA on the proliferation induced by mitogen in splenocytes of mice exposed to X-rays in vitro and in vivo. The results showed that in vitro, HL-RNA control ConA-induced proliferation of spleen cells significantly inhibited, and with the increase of HL-RNA concentration increased inhibition. However, different concentration of HL-RNA could promote ConA and LPS-induced proliferative responses of mouse spleen cells after in vivo irradiation. When the concentration of HL-RNA was more than 6.25mg / kg body weight, there was a significant difference between the irradiated group and the control group. Simultaneous determination of ConAfoLPS-induced proliferative responses of mouse splenocytes after HL-RNA-induced serum irradiation was also significantly enhanced. Tip, HL-RNA in vitro and in vivo effects of irradiation on the proliferation of mouse spleen cells have different effects.