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目的：比较 Ｇ Ｆ 和沙林的家兔整体透皮吸收特点。方法： Ｇ Ｆ 和沙林在家兔皮肤染毒后，于不同时间采血测定全血乙酰胆碱酯酶（ Ａ Ｃｈ Ｅ）活力，用 Ｌｏｇｉｔ 方法算出抑制 ５０％ Ａ Ｃｈ Ｅ 活力所需时间。将 １ ｍ ｇ／ Ｌ 浓度的毒剂，以 ０．５ ｍ ｌ／ｍ ｉｎ 的输液速度静脉途径中毒，不同时间采血测定 Ａ Ｃｈ Ｅ活力，同法算出抑制 ５０％ Ａ Ｃｈ Ｅ 时进入体内的毒剂量。由此推算出毒剂的透皮速率。结果： Ｇ Ｆ和沙林在皮肤的延搁期均在１ ｍ ｉｎ 以内。 Ｇ Ｆ 的透皮速率比沙林快 １ 倍。静脉途径中毒后， Ｇ Ｆ 的抑酶能力比沙林强 １２ 倍。结论： Ｇ Ｆ 和沙林能通过皮肤吸收，具有皮肤延搁期短、抑酶能力强等特点，在实战条件下， 其皮肤防护是一个不容忽视的问题。
OBJECTIVE: To compare the overall transdermal absorption characteristics of G F and sarin rabbits. Methods: G F and sarin were collected from the skin of rabbits and the blood samples were collected at different times to determine the activity of acetylcholinesterase (A ChE). Logit method was used to calculate the time required to inhibit the activity of 50% A Ch E. A 1 m g / L concentration of toxic agents, 0.5 m l / m in infusion rate of intravenous route of poisoning, blood was collected at different times to determine A Ch E activity, the same method to calculate the inhibition of 50% A Ch E into the body when the dose . Based on this, the transdermal rate of the toxicant is calculated. Results: Both GF and sarin had skin lodgment of less than 1 mins. The transdermal rate of G F is 1 time faster than sarin. After intravenous route poisoning, G F inhibition of enzyme capacity than Shalin 1 2 times. Conclusion: G F and sarin can be absorbed through the skin, with short skin delay and strong ability of inhibiting enzymes. Under actual combat conditions, skin protection is a problem that can not be ignored.