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应用口服避孕药(OC_2)可引起心血管疾病的危险增加,可能是由于 OC_2造成代谢的改变,提示脂蛋白和碳水化合物的改变在这方面是重要的。危险增加不仅与每天剂量的雌激素成份有关而且也与孕激素剂量成份有关。最近发现 OC_(?)治疗期间,主要阿朴蛋白 apo A-I 和 apoB 可有改变,OC_(?)中炔雌醇(EE)含量<50μg 和低剂量的孕激素时,碳水化合物的代谢改变最小。本文研究了含有30μgEE 和150μg deso-gestrel 或左旋18甲基炔诺酮两种OC_(?)对血清胆固醇、甘油三酯、HDL-C、apoA-
The use of oral contraceptives (OC2) can cause an increased risk of cardiovascular disease, possibly due to metabolic changes in OC2, suggesting that changes in lipoproteins and carbohydrates are important in this regard. The increased risk is associated not only with the daily dose of estrogen but also with the progestin dose component. Recently, it has been found that the major apapoproteins, apo A-I and apoB, can be altered during the treatment of OC_ (?), With minimal alterations of carbohydrate metabolism when the ethinyl estradiol (EE) In this paper, we investigated the effect of OC? (?) With 30μgEE and 150μg deso-gestrel or levonorgestrel 18 on serum cholesterol, triglycerides, HDL-C, apoA-