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(一)由急性麻醉动物实驗証明,大白鼠受到Co~(60)丙种射綫1294倫一次全身照射后,第24小时小腸对葡萄糖的选擇性吸收能力与对照組无显著差別;第48小时則明显下降;第72小时降低更甚,此时小腸粘膜对葡萄糖的选擇性吸收能力几乎完全丧失,降到非选择性吸收水平。照射后第48及72小时,小腸对木糖的吸收能力亦发生輕度的降低。 (二)照射后上段与下段小腸吸收机能变化的趋势基本上是一致的,但上段小腸对射綫作用更为敏感。 (三)用离体小腸制备証明,照射后24及48小时,离体的小腸粘膜仍然保持了对葡萄糖的主动轉移及选擇性吸收能力。文中指出了第48小时组离体实驗与整体实驗出現不同的結果。 (四)照射后72小时,离体的小腸粘膜已丧失了其主动轉移能力及选擇性吸收能力,此时葡萄糖不能自粘膜侧进入小腸組織,对木糖的通透性亦降低,但对放射性碘自粘膜侧向浆膜侧的通透性則反較正常为高。此时小腸粘膜的改变很近似根皮苷0.004M中毒时的情况;亦有些类似2,4-二硝基酚10~(-4)M中毒时的情况。
(A) from acute anesthesia animal experiments show that the rat by Co ~ (60) C rays 1294 Lun a systemic irradiation, the first 24 hours of small intestine glucose selective absorption capacity and the control group no significant difference; the first 48 hours Then significantly decreased; the first 72 hours to reduce even more, this time the selective absorption of small intestinal mucosa of glucose almost completely lost to non-selective absorption levels. 48 and 72 hours after irradiation, the intestinal absorption of xylose also mildly reduced. (B) after irradiation, upper and lower intestine absorption function of the trend is basically the same, but the upper small intestine is more sensitive to the role of radiation. (C) with the preparation of isolated small intestine proof, 24 and 48 hours after irradiation, isolated small intestinal mucosa still maintained the active transfer of glucose and selective absorption capacity. The article pointed out in the first 48 hours group experiments in vitro and the overall experiment with different results. (D) 72 hours after irradiation, ex vivo small intestinal mucosa has lost its active ability to transfer and selective absorption of glucose at this time from the mucosal side into the small intestine, the permeability of xylose also decreased, but for Radioactive iodine from the mucosal side of the serosal permeability than the normal high. Small intestinal mucosal changes at this time is very similar to the case of phlorizin 0.004M poisoning; also some similar 2,4-dinitrophenol 10 ~ (-4) M poisoning situation.