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细胞间粘附分子-1(ICAM-1)是免疫球蛋白基因超家族成员,为90-114kd糖蛋白,分布在细胞表面,炎症时具有介导细胞间粘附、提呈抗原和促进炎细胞穿越内皮和上皮等重要作用;可溶性ICAM-1(sICAM-1)存在于正常人周围血中,在免疫功能紊乱时明显升高。观察过敏性气道炎症时支气管肺泡灌洗液(BALF)中sICAM-1浓度,探讨其与血清中sICAM-1浓度及BALF中细胞学改变的关系。 对象和方法11例(男7,女4)无症状不吸烟鼻炎患者(n=3)和鼻炎合并哮喘患者(n=8),平均年龄28.6岁,9种常见吸入性过敏原皮试阳性作为激发抗原。首次支气管肺泡灌洗(BAL)取右肺上叶,生理盐水
Intercellular adhesion molecule-1 (ICAM-1), a member of the immunoglobulin superfamily, is a 90-114 kd glycoprotein that distributes on the cell surface and mediates cell-cell adhesion, antigen presentation, and proinflammatory cytokines Through the endothelium and epithelium and other important role; soluble ICAM-1 (sICAM-1) exists in normal human peripheral blood, significantly increased in immune dysfunction. The concentration of sICAM-1 in bronchoalveolar lavage fluid (BALF) during allergic airway inflammation was observed and its relationship with serum concentration of sICAM-1 and cytological changes in BALF was investigated. Subjects and Methods Eleven patients (male 7, female 4) with asymptomatic non-smoking rhinitis (n = 3) and rhinitis with asthma (n = 8), mean age 28.6 years old, were tested positive for 9 common inhaled allergens antigen. The first bronchoalveolar lavage (BAL) take the right upper lobe, saline