论文部分内容阅读
目的探讨血清胱肽素C和同型半胱氨酸与早期糖尿痛肾病的关系。方法 2010年4月至2012年4月期间,我院诊治的60例2型糖尿病患者,根据糖尿病肾病诊断标准,将其分为糖尿病肾病组和糖尿病无肾病组,每组各30例,以及30例健康体检者作为正常对照组,对三组患者的糖化血红蛋白水平、肌酐、尿素氮、微量清蛋白尿排泄率(UAER)、血清胱肽素C(CysC),以及同型半胱氨酸(Hcy),进行检测和比较。结果与正常对照组、糖尿病无肾病组相比,糖尿病肾病组患者的肌酐(t=3.12,t=2.34)、尿素氮(t=3.34,t=2.14),以及微量清蛋白尿排泄率(t=5.32,t=2.53)明显升高,P<0.05;与正常对照组相比,糖尿病无肾病组和糖尿病肾病组患者的糖化血红蛋白水平明显升高(t=2.17,t=2.46),P<0.05;与糖尿病无肾病组相比,糖尿病肾病组胱肽素C(t=2.19)和同型半胱氨酸水平(t=2.32)均明显升高,P<0.05。结论定期检测胱肽素C与同型半胱氨酸水平,可以及早糖尿病患者的早期肾损伤,值得临床推广。
Objective To investigate the relationship between serum cystatin C, homocysteine and early diabetic nephropathy. Methods From April 2010 to April 2012, 60 type 2 diabetic patients diagnosed and treated in our hospital were divided into diabetic nephropathy group and diabetic nephropathy group according to the diagnostic criteria of diabetic nephropathy, 30 cases in each group and 30 cases in each group Cases of healthy subjects as a normal control group, the three groups of patients with glycosylated hemoglobin levels, creatinine, urea nitrogen, urinary albumin excretion rate (UAER), serum cystatin C (CysC), and homocysteine (Hcy ) For testing and comparison. Results Compared with normal control group and diabetic nephropathy group, creatinine (t = 3.12, t = 2.34), urea nitrogen (t = 3.34, t = 2.14) and urinary albuminuria excretion rate (T = 2.17, t = 2.46), P <0.05). Compared with the normal control group, the levels of HbA1c in diabetic nephropathy group and diabetic nephropathy group were significantly higher (t = 2.17, t = 0.05). Compared with diabetic nephropathy group, the levels of serum Cysteamine C (t = 2.19) and homocysteine (t = 2.32) in diabetic nephropathy group were significantly increased, P <0.05. Conclusion Regular detection of cysteamine C and homocysteine levels, early diabetic patients with early renal injury, is worthy of clinical promotion.