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已有研究表明,母体孕期接受抗原刺激,其子代在出生后的一段时期内对相应抗原的免疫应答受到抑制,但该现象的确切机理尚不清楚。本文作者对此进行了研究。所用的蛋白抗原为光照氧化的花粉抗原(OX-AgB)及三硝基酚-牛丙种球蛋白(TNP-BGG),于妊娠第7天,上述两种抗原与明矾混合后分别给母鼠免疫,对照组仅注射明矾。各组新生小鼠在生后第6、8、16周分别接受与母体相同的抗原免疫,在初次免疫后的第21天再以相应抗原二次免
It has been shown that when mothers are exposed to antigen during pregnancy, the immune response of their offspring to the corresponding antigen is inhibited during the postnatal period. However, the exact mechanism of this phenomenon is not clear. The author of this article has carried on the research. The protein antigens used were light-oxidized pollen antigen (OX-AgB) and trinitrophenol-bovine gamma globulin (TNP-BGG). On the 7th day of gestation, the two antigens were mixed with alum The control group only injected alum. Newborn mice in each group were immunized with the same antigen as the maternal at the 6th, 8th and 16th weeks after birth, respectively, on the 21st day after the first immunization,