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目的:探讨小剂量红霉素治疗极低出生体质量儿喂养不耐受症状的临床效果。方法:选取本院2013年1月-2014年2月收治的极低出生体质量儿喂养不耐受患儿共84例作为研究对象,使用随机数字表法分为观察组以及对照组各42例。两组患儿均给予保暖、静脉营养、水电解质平衡、酸碱平衡、鼻饲微量喂养以及非营养性吸吮等综合治疗,观察组患儿在上述治疗基础上添加小剂量红霉素稀释静脉滴注,观察两组患儿治疗效果,观察两组患儿自行吸吮母乳时间、恢复出生体质量时间、进入足量胃肠喂养时间、胃管滞留时间以及整体住院时间等临床指标,观察两组患儿治疗过程中不良反应发生率。结果:观察组患儿治疗有效率97.6%,对照组患儿治疗有效率83.3%(P<0.05)。观察组患儿开始自行吸吮母乳时间、恢复出生体质量时间、可以足量胃肠喂养时间、患儿胃管滞留时间以及整体住院时间均明显少于对照组(P<0.05)。两组患儿治疗过程中均未出现较为明显的不良反应,不存在排便次数增加或者异常哭闹症状,患儿治疗前后肝肾功能检查并无异常变化(P>0.05)。结论:在常规临床治疗上添加小剂量红霉素治疗极低出生体质量儿喂养不耐受症状有着良好的临床效果,能够有效缩短患儿恢复自行吸吮母乳时间,促进患儿恢复正常体质量,同时不良反应发生率低。
Objective: To investigate the clinical effect of low-dose erythromycin in the treatment of intolerant symptoms of very low birth weight children. Methods: A total of 84 infants with very low birth weight who were admitted to our hospital from January 2013 to February 2014 were enrolled in this study. The random number table was divided into observation group and control group, with 42 cases in each group . Two groups of children were given warmth, intravenous nutrition, water and electrolyte balance, acid-base balance, nasogastric micronutrient feeding and non-nutritional sucking and other comprehensive treatment of children in the observation group in the treatment based on the addition of small doses of erythromycin dilution intravenous , Observed the therapeutic effect of two groups of children, observe the two groups of children suck breast milk time, restore birth weight time, into adequate gastrointestinal feeding time, gastric tube residence time and overall hospital stay and other clinical indicators observed two groups of children The incidence of adverse reactions during treatment. Results: The effective rate of treatment group was 97.6% in observation group and 83.3% in control group (P <0.05). Children in the observation group started to suck breast milk on their own, and recovered the time of birth weight, enough time for gastrointestinal feeding, gastric tube retention time and overall length of hospital stay in the observation group were significantly less than those in the control group (P <0.05). There was no significant adverse reactions in the treatment of both groups, there was no increase in the frequency of defecation or abnormal crying symptoms, no abnormal changes in liver and kidney function tests before and after treatment (P> 0.05). Conclusion: The addition of small doses of erythromycin in routine clinical treatment of very low birth weight children with symptoms of feeding intolerance has a good clinical effect, which can effectively shorten the recovery of children suckling breast milk time and promote normal return to normal weight, At the same time the incidence of adverse reactions is low.