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目的:探讨乳腺癌中医证候与肿瘤微血管生成特点的关系。方法:对72例乳腺癌女性患者中医辨证分型,并进行常规彩色多普勒超声、超声造影技术及肿瘤病理学指标检查,对不同证型组的各项指标进行对比分析。结果:①肿瘤血流级别正虚毒炽组与肝郁痰凝组、冲任失调组比较,差异均无显著性意义(P>0.05),肝郁痰凝组与冲任失调组比较,差异无显著性意义(P>0.05)。②超声造影肿物增强形态正虚毒炽组与肝郁痰凝组、冲任失调组比较,差异均有显著性意义(P<0.05),肝郁痰凝组与冲任失调组比较,差异有显著性意义(P<0.05)。③病理分级正虚毒炽组与肝郁痰凝组、冲任失调组比较,差异均有显著性意义(P<0.05):肝郁痰凝组与冲任失调组比较,差异有显著性意义(P<0.05)。④正虚毒炽组微血管计数高于肝郁痰凝组和冲任失调组,差异均有显著性意义(P<0.05);肝郁痰凝组和冲任失调组比较,差异无显著性意义(P>0.05)。⑤3个证型组间血管内皮生成因子(VEGF)强度和VEFG百分比比较,差异均无显著性意义(P>0.05)。结论:乳腺癌微血管形态学指标与临床中医辨证分型之间存在一定的联系,因此根据肿瘤微血管形态特征可以对中医辨证提供客观的定量分析。
Objective: To investigate the relationship between TCM syndromes and tumor angiogenesis in breast cancer. Methods: 72 cases of breast cancer patients with TCM syndrome differentiation, and routine color Doppler ultrasound, contrast-enhanced ultrasound and tumor pathological examination, the indicators of different syndrome groups were analyzed. Results: ① There was no significant difference in the level of tumor blood flow between Zhengxu Chi group and liver depression phlegm-condensing group and Chong-Ren-Tu imbalance group (P> 0.05) No significant (P> 0.05). (2) There was significant difference between the two groups (P <0.05), and the difference between the group of liver-qi and phlegm-dampness and the group of Chong-Ren-Shen disorders There was significant (P <0.05). (3) The pathological grade was positive and poisonous Chi group and liver Yu sputum coagulation group, Chong Ren Ren offset group, the difference was statistically significant (P <0.05): liver Yu phlegm coagulation group and Chong and Ren imbalance group, the difference was statistically significant (P <0.05). (4) The microvessel count of the positive virtual poisoning group was higher than that of the liver stagnation and phlegm coagulation group and the Chong and Ren derangement group (P <0.05); there was no significant difference between the liver stagnation and phlegm coagulation group and the Chong and Ren derangement group (P> 0.05). ⑤ There was no significant difference between the three syndrome groups in the intensity of vascular endothelial growth factor (VEGF) and the percentage of VEFG (P> 0.05). Conclusion: There is a certain relationship between microvascular morphological characteristics of breast cancer and clinical syndrome differentiation. Therefore, based on the characteristics of tumor microvessels, objective and quantitative analysis of TCM syndrome differentiation can be provided.