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目的:探讨卡比多巴-左旋多巴控释片治疗帕金森病合并睡眠障碍患者的临床疗效。方法:选取2015年1月到2016年1月于我院就诊的帕金森病合并睡眠障碍患者共74例,将患者按照入院编号,随机分为两组,观察组和对照组患者各37例,对照组患者入院之后给予其艾司唑仓治疗;观察组患者采用卡比多巴-左旋多巴控释片进行治疗,比较两组患者的治疗效果。结果:观察组37例患者在接受卡比多巴-左旋多巴控释片治疗之后,无不良反应的发生;对照组患者发生不良反应的概率为13.5%。观察组患者接受卡比多巴-左旋多巴控释片治疗之后匹茨堡睡眠质量评分和帕金森病评定评分,较之对照组患者的匹茨堡睡眠质量评分和帕金森病评定评分都比较低,比较两组患者的治疗效果。观察组患者治疗效果要明显高于对照组患者,组间治疗效果比较具有明显差异,P<0.05。结论:临床上在治疗帕金森病合并睡眠障碍时,可以采用卡比多巴-左旋多巴控释片的治疗方法,获得非常理想的治疗效果,安全有效值得在临床上大力推广。
Objective: To investigate the clinical efficacy of carbidopa-levodopa controlled release tablets in patients with Parkinson’s disease complicated with sleep disorders. Methods: A total of 74 patients with Parkinson’s disease and sleep disorders admitted to our hospital from January 2015 to January 2016 were selected. Patients were randomly divided into two groups according to admission number, 37 cases in observation group and control group, The patients in the control group were treated with eszotrazone after admission. The patients in the observation group were treated with controlled-release tablets of carbidopa-levodopa, and the therapeutic effect was compared between the two groups. Results: There were no adverse reactions in 37 patients in the observation group after receiving the controlled release of carbidopa-levodopa. The incidence of adverse reactions in the control group was 13.5%. Patients in the observation group received Pittsburgh Sleep Quality Score and Parkinson’s Disease Rating score after treatment with carbidopa-levodopa, compared with Pittsburgh Sleep Quality Score and Parkinson’s Disease Rating score in the control group Low, comparing the treatment effect of two groups of patients. The treatment effect of the observation group was significantly higher than that of the control group, the treatment effect was significantly different between groups (P <0.05). Conclusion: Clinic treatment of Parkinson’s disease combined with sleep disorders, you can use carbidopa - Levodopa controlled release tablets treatment, to obtain a very good therapeutic effect, safe and effective deserved in clinical promotion.