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实验观察了从原发性高血压病患者红细胞中提取的抗高血压因子(AHF)对自发性高血压大鼠(SHR)、肾性高血压大鼠(RHR)和正常血压的WKY大鼠和Wistar大鼠主动脉和肠系膜动咏平滑肌Ca~(2+)内流的影响。结果表明,SHR和RHR的肠系膜动脉Ca~(2+)内流显著高于主动脉;AHF可显著抑制SHR和RHR主动脉和肠系膜动脉Ca~(2+)内流,抑制作用呈剂量依赖性,且对肠系腆动脉Ca~(2+)内流抑制作用更明显;AHF也可抑制正常动物血管平滑肌Ca~(2+)内流。本工作提示,AHF的降压机制可能与其抑制血管平滑肌特别是小动脉血管平滑肌Ca~(2+)内流有关。
The effects of antihypertensive factor (AHF) extracted from erythrocytes of primary hypertension patients on spontaneous hypertensive rats (SHR), renal hypertensive rats (RHR) and normotensive WKY rats Effect of Ca ~ (2 +) influx on the aorta and mesenteric ape smooth muscle of Wistar rats. The results showed that the Ca ~ (2+) influx in the mesenteric artery of SHR and RHR was significantly higher than that of the aorta; AHF significantly inhibited Ca ~ (2+) influx in the aorta and mesenteric artery of SHR and RHR, and the inhibitory effect was dose - dependent , And the inhibitory effect on Ca ~ (2+) influx in the popliteal artery was more obvious. AHF also inhibited Ca ~ (2+) influx in the vascular smooth muscle of normal animals. This work suggests that the antihypertensive mechanism of AHF may be related to its inhibition of Ca ~ (2+) influx in vascular smooth muscle, especially in arteriole smooth muscle.