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紫杉醇为广谱有效的抗实体瘤药物,用于宫颈癌患者治疗已进行广泛临床研究,证实其可靠有效。从单药、双药及三药化疗等方面,综述近年紫杉醇治疗宫颈癌的临床应用。紫杉醇(T)联合顺铂(P)或卡铂(C)化疗方案优于紫杉醇单药或三药化疗,安全有效。尤其在新辅助化疗中;与顺铂相比,卡铂肾毒性小,无需水化,TC方案相对简单;TP或TC配合放疗疗效显著;紫杉醇周疗与3周疗法比较疗效类似,不良反应较小。
Paclitaxel is a broad spectrum of effective anti-solid tumor drugs for cervical cancer patients have been extensive clinical studies have confirmed its reliable and effective. From single drug, double drug and three drug chemotherapy, review the clinical application of paclitaxel in the treatment of cervical cancer in recent years. Paclitaxel (T) combined with cisplatin (P) or carboplatin (C) chemotherapy is superior to paclitaxel single or triple drug chemotherapy, safe and effective. Especially in neoadjuvant chemotherapy; compared with cisplatin, carboplatin nephrotoxicity is small, without hydration, TC program is relatively simple; TP or TC with radiotherapy significantly; paclitaxel week treatment and 3 weeks of similar efficacy, adverse reactions than small.